Sugi Predict

Sugi Predict / Compounds / SCHEMBL7181301

SCHEMBL7181301

SCHEMBL7181301

COc1ccc([PH](=O)C(=O)c2c(C(F)(F)F)cccc2C(F)(F)F)c(OC)c1C(=O)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MRGPRX4 Q96LA9 2/20 0.38
▸ KDM4E B2RXH2 3/20 0.37
▸ ALOX15 P16050 2/20 0.37
▸ MAPK1 P28482 2/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ HTT P42858 2/20 0.37
▸ TP53 P04637 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ MAPT P10636 3/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ SLC6A9 P48067 1/20 0.37
▸ CYP1A2 P05177 2/20 0.36
▸ CYP2C19 P33261 2/20 0.36
▸ CYP2D6 P10635 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ LMNA P02545 3/20 0.36
▸ ATM Q13315 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7177181 0.87 CA12 (0.44) KDM4EALOX15MAPK1MEN1KMT2A
SCHEMBL7188255 0.84 MAPT (0.40) KDM4EALOX15MAPK1MEN1KMT2A
SCHEMBL7178311 0.83 MRGPRX4 (0.39) MRGPRX4KDM4EMEN1KMT2AMAPT
SCHEMBL7183306 0.83 TUBB4A (0.41) KDM4EALOX15MAPK1MEN1KMT2A
SCHEMBL7180436 0.82 TUBB4A (0.40) KDM4EALOX15MAPK1MEN1KMT2A
SCHEMBL7187912 0.81 HPGD (0.41) KDM4EALOX15MAPK1KMT2AHTT
SCHEMBL7722888 0.80 MRGPRX4 (0.40) MRGPRX4KDM4EALOX15MAPK1MEN1
SCHEMBL7735674 0.80 MAOB (0.36) MRGPRX4KDM4EMEN1KMT2AHTT
SCHEMBL7175680 0.80 HPGD (0.40) KDM4EALOX15MAPK1HTTTP53
SCHEMBL7180896 0.79 TUBB4A (0.39) KDM4EALOX15MAPK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MRGPRX4 3913/4885KDM4E 3226/4885ALOX15 1458/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MRGPRX4 4163/4885KDM4E 2651/4885ALOX15 1122/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.