Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.57 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | JAK1 | P23458 | 5/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | TPH1 | P17752 | 1/20 | 0.39 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182076 | 1.00 | TNKS (0.57) | TNKSTNKS2PRKDCJAK2JAK3 | |
| SCHEMBL16456358 | 0.88 | TNKS (0.60) | TNKSTNKS2JAK2JAK3JAK1 | |
| SCHEMBL7191729 | 0.84 | TNKS (0.54) | TNKSTNKS2PRKDCJAK2JAK3 | |
| SCHEMBL7191736 | 0.84 | TNKS (0.54) | TNKSTNKS2PRKDCJAK2JAK3 | |
| SCHEMBL7185342 | 0.78 | TNKS (0.59) | TNKSTNKS2OPRM1PGR | |
| SCHEMBL7185339 | 0.78 | TNKS (0.59) | TNKSTNKS2OPRM1PGR | |
| SCHEMBL7190967 | 0.75 | PRKDC (0.49) | TNKSTNKS2PRKDCJAK2JAK3 | |
| SCHEMBL7190974 | 0.75 | PRKDC (0.49) | TNKSTNKS2PRKDCJAK2JAK3 | |
| SCHEMBL16455985 | 0.74 | JAK2 (0.49) | TNKSTNKS2PRKDCJAK2JAK3 | |
| SCHEMBL28514019 | 0.74 | JAK2 (0.47) | TNKSTNKS2PRKDCJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |