Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | TPH1 | P17752 | 1/20 | 0.43 |
| ▸ | TPH2 | Q8IWU9 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7190974 | 1.00 | PRKDC (0.49) | PRKDCJAK2JAK1JAK3TPH1 | |
| SCHEMBL20468291 | 0.95 | PRKDC (0.43) | PRKDCJAK2JAK1JAK3TPH1 | |
| SCHEMBL7184792 | 0.79 | ALDH1A1 (0.54) | TPH1TPH2ALDH1A1KDM4EHTT | |
| SCHEMBL7184789 | 0.79 | ALDH1A1 (0.54) | TPH1TPH2ALDH1A1KDM4EHTT | |
| SCHEMBL26350854 | 0.78 | PLAT (0.40) | JAK2JAK1JAK3TPH1TPH2 | |
| SCHEMBL7182076 | 0.75 | TNKS (0.57) | PRKDCJAK2JAK1JAK3TPH1 | |
| SCHEMBL7182072 | 0.75 | TNKS (0.57) | PRKDCJAK2JAK1JAK3TPH1 | |
| SCHEMBL30534158 | 0.74 | PIK3CA (0.41) | PRKDCPIK3CAMTORKDM4E | |
| SCHEMBL27153219 | 0.74 | PIK3CA (0.41) | PRKDCPIK3CAMTORKDM4E | |
| SCHEMBL18477021 | 0.73 | ALDH1A1 (0.58) | ALDH1A1KDM4EHTTKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |