Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182554 | 1.00 | ESR1 (0.52) | ESR1ESR2CYP1A1CYP1B1KDM4E | |
| SCHEMBL7184010 | 0.89 | ESR1 (0.43) | ESR1ESR2CYP1A1CYP1B1KDM4E | |
| SCHEMBL7184005 | 0.89 | ESR1 (0.43) | ESR1ESR2CYP1A1CYP1B1KDM4E | |
| SCHEMBL7185012 | 0.87 | ESR1 (0.50) | ESR1ESR2ABCG2 | |
| SCHEMBL7185015 | 0.87 | ESR1 (0.50) | ESR1ESR2ABCG2 | |
| SCHEMBL7186129 | 0.86 | ESR1 (0.61) | ESR1ESR2CYP1A1CYP1B1KDM4E | |
| SCHEMBL7186132 | 0.86 | ESR1 (0.61) | ESR1ESR2CYP1A1CYP1B1KDM4E | |
| SCHEMBL7195203 | 0.84 | ESR1 (0.58) | ESR1ESR2CYP1A1CYP1B1ABCG2 | |
| SCHEMBL7195206 | 0.84 | ESR1 (0.58) | ESR1ESR2CYP1A1CYP1B1ABCG2 | |
| SCHEMBL7190635 | 0.84 | ESR1 (0.52) | ESR1ESR2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |