Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.88 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.80 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.74 |
| ▸ | THPO | P40225 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180763 | 1.00 | SLC29A1 (0.88) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL20579790 | 0.96 | SLC29A1 (0.85) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL8328951 | 0.95 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL10886676 | 0.95 | SLC29A1 (0.80) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL31628603 | 0.95 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL6758644 | 0.95 | SLC29A1 (0.98) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL5675415 | 0.95 | SLC29A1 (0.80) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL5675424 | 0.95 | SLC29A1 (0.80) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL6762621 | 0.94 | SLC29A1 (0.83) | SLC29A1ADORA1ADORA3ADORA2ATSHR | |
| SCHEMBL20705944 | 0.93 | SLC29A1 (0.80) | SLC29A1ADORA1ADORA3ADORA2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030125298-A1 | Cancer therapy comprising deaminase enzyme inhibitors | CTRE DE RECHERCHE INDUST. DU QUEBEC (CA) | 2003-07-03 | — | — | US | disclosed |
| US-6579857-B1 | Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors | EVANSTON NORTHWESTERN HEALTHCARE RESEARCH INSTITUTE | 2003-06-17 | — | — | US | disclosed |
| WO-2000076524-A1 | COMBINATION CANCER THERAPY COMPRISING ADENOSINE AND DEAMINASE ENZYME INHIBITOR | EVANSTON NORTHWESTERN HEALTHCARE RESEARCH INSTITUTE (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5646128-A | TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS | GENSIA, INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1992012718-A1 | ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1992-08-06 | — | — | WO | disclosed |