Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005130 | 0.90 | TP53 (0.35) | TP53LMNAKMT2AALDH1A1DPP4 | |
| SCHEMBL7560366 | 0.88 | PTGER1 (0.37) | KMT2AKDM4EBRD4MCHR1 | |
| SCHEMBL7556767 | 0.80 | DPP4 (0.37) | DPP4ICMTBRD4 | |
| SCHEMBL5239007 | 0.70 | DPP4 (0.54) | DPP4 | |
| SCHEMBL7595947 | 0.63 | DPP4 (0.39) | DPP4ICMT | |
| SCHEMBL5232923 | 0.60 | DPP4 (0.57) | DPP4 | |
| SCHEMBL1381646 | 0.60 | HK2 (0.40) | TP53LMNAALDH1A1BRD4 | |
| SCHEMBL5238084 | 0.59 | DPP4 (0.55) | PDE5ADPP4 | |
| SCHEMBL5234802 | 0.59 | DPP4 (0.64) | DPP4 | |
| SCHEMBL5234230 | 0.59 | DPP4 (0.52) | DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355886-A1 | FUSED HETEROCYCLIC COMPOUNDS | Takeda Chemical Industries, Ltd. (JP) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002062764-A1 | FUSED HETEROCYCLIC COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-15 | — | — | WO | disclosed |