Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187993 | 0.92 | ESR1 (0.52) | ESR1ESR2CYP4F2CYP4A11FFAR1 | |
| SCHEMBL7185068 | 0.90 | MAPT (0.46) | CYP4F2CYP4A11FFAR1KDM4EALDH1A1 | |
| SCHEMBL7195102 | 0.89 | CYP4F2 (0.46) | ESR1ESR2CYP4F2CYP4A11FFAR1 | |
| SCHEMBL7190740 | 0.87 | FFAR1 (0.53) | ESR1ESR2FFAR1FFAR4AKR1B1 | |
| SCHEMBL7190011 | 0.87 | ESR1 (0.50) | ESR1ESR2 | |
| SCHEMBL7190451 | 0.85 | ESR1 (0.55) | ESR1ESR2CYP4F2CYP4A11FFAR1 | |
| SCHEMBL7195351 | 0.85 | MAPT (0.47) | ESR1ESR2CYP4F2CYP4A11FFAR1 | |
| SCHEMBL7181210 | 0.85 | ESR1 (0.54) | ESR1ESR2 | |
| SCHEMBL7193207 | 0.83 | ESR1 (0.49) | ESR1ESR2CYP4F2CYP4A11KDM4E | |
| SCHEMBL7194279 | 0.83 | CYP1A2 (0.47) | ESR1ESR2CYP4F2CYP4A11FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |