SCHEMBL7184426

SCHEMBL7184426

Cc1cc(C)c(C(=O)[P](=O)c2ccccc2C(=O)c2c(Br)cccc2Br)c(C)c1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
ALDH1A1 P00352 5/20 0.34
LMNA P02545 4/20 0.34
HPGD P15428 4/20 0.34
SMN1; SMN2 Q16637 4/20 0.34
MAPT P10636 2/20 0.34
HTT P42858 2/20 0.34
CNR2 P34972 2/20 0.34
CNR1 P21554 1/20 0.32
RAB9A P51151 2/20 0.32
BCL2L1 Q07817 1/20 0.32
PRNP P04156 1/20 0.31
POLB P06746 1/20 0.31
HSD17B10 Q99714 1/20 0.31
F2R P25116 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7183120 0.91 CNR2 (0.36) KMT2AALDH1A1HPGDSMN1; SMN2MAPT
SCHEMBL7183573 0.88 KMT2A (0.39) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL7180500 0.88 KMT2A (0.39) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL7182240 0.88 CNR2 (0.33) KMT2ALMNAHPGDMAPTCNR2
SCHEMBL7187205 0.85 KMT2A (0.39) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL7181110 0.85 MEN1 (0.47) MEN1KMT2AALDH1A1LMNACNR2
SCHEMBL7188528 0.84 KMT2A (0.38) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL7180124 0.84 MEN1 (0.38) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL7174639 0.83 MEN1 (0.37) MEN1KMT2AALDH1A1LMNAHPGD
SCHEMBL7186638 0.83 MEN1 (0.42) MEN1KMT2AALDH1A1LMNAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MEN1 2312/4885KMT2A 1586/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MEN1 2263/4885KMT2A 956/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.