Sugi Predict

Sugi Predict / Compounds / SCHEMBL7188528

SCHEMBL7188528

SCHEMBL7188528

Cc1cc(C)c(C(=O)[P](=O)c2ccccc2C(=O)c2c(C)c(C)cc(C)c2C)c(C)c1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 6/20 0.38
▸ MEN1 O00255 4/20 0.38
▸ ALDH1A1 P00352 4/20 0.32
▸ LMNA P02545 3/20 0.32
▸ GAA P10253 1/20 0.32
▸ HPGD P15428 3/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ CRHBP P24387 1/20 0.32
▸ CRHR2 Q13324 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31
▸ MCOLN3 Q8TDD5 1/20 0.31
▸ CRHR1 P34998 2/20 0.31
▸ BCL2L1 Q07817 1/20 0.31
▸ ABCB1 P08183 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ CYP2C9 P11712 1/20 0.31
▸ POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180044 0.93 KMT2A (0.37) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7187205 0.93 KMT2A (0.39) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7174639 0.91 MEN1 (0.37) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7180523 0.91 KMT2A (0.37) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7178036 0.90 KMT2A (0.37) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7180482 0.90 ALDH1A1 (0.33) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7174862 0.88 GFER (0.35) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7183573 0.88 KMT2A (0.39) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7180500 0.88 KMT2A (0.39) KMT2AMEN1ALDH1A1LMNAGAA
SCHEMBL7181631 0.86 ALDH1A1 (0.33) KMT2AMEN1ALDH1A1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMT2A 1586/4885MEN1 2312/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMT2A 956/4885MEN1 2263/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.