Sugi Predict

Sugi Predict / Compounds / SCHEMBL7184483

SCHEMBL7184483

SCHEMBL7184483

Cc1cccc(Cl)c1C(=O)Pc1ccc(OC(C)C)cc1.[LiH]

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TYK2 P29597 1/20 0.39
▸ POLB P06746 1/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ PARP10 Q53GL7 1/20 0.37
▸ ITGB1 P05556 4/20 0.36
▸ ITGA4 P13612 4/20 0.36
▸ ITGA2 P17301 1/20 0.36
▸ ITGB7 P26010 1/20 0.36
▸ TP53 P04637 3/20 0.35
▸ MAPT P10636 2/20 0.35
▸ GLA P06280 1/20 0.35
▸ GAA P10253 3/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ LMNA P02545 2/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ PPARG P37231 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7186881 0.93 POLB (0.43) POLBKMT2APARP10TP53MAPT
SCHEMBL7188453 0.91 POLB (0.43) POLBKMT2APARP10TP53MAPT
SCHEMBL7179822 0.90 TYK2 (0.34) TYK2ITGB1ITGA4ITGA2ITGB7
SCHEMBL7181454 0.88 ACACB (0.36) TYK2ITGB1ITGA4ITGA2ITGB7
SCHEMBL7181233 0.86 ALDH1A1 (0.40) POLBKMT2APARP10ITGB1ITGA4
SCHEMBL7175370 0.86 ITGB1 (0.34) TYK2POLBKMT2AITGB1ITGA4
SCHEMBL7182030 0.85 KMT2A (0.41) TYK2POLBKMT2AMAPTALDH1A1
SCHEMBL7177496 0.85 TYK2 (0.37) TYK2POLBKMT2AITGB1ITGA4
SCHEMBL7187939 0.84 NR1H4 (0.37) POLBKMT2ATP53MAPTGAA
SCHEMBL7185568 0.83 FABP3 (0.40) TYK2KMT2APARP10MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 TYK2 1285/4885POLB 2322/4885KMT2A 1586/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 TYK2 1333/4885POLB 2993/4885KMT2A 956/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.