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Sugi Predict / Compounds / Morpholine

Morpholine

Morpholine

SCHEMBL7184584

C1COCCN1.O=C1CCN(Cc2ccccc2)CC1c1ccc(Cl)c(Cl)c1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SIGMAR1 Q99720 3/20 0.43
▸ TACR1 P25103 8/20 0.43
▸ DRD4 P21917 1/20 0.39
▸ SLC6A2 P23975 4/20 0.39
▸ SLC6A4 P31645 4/20 0.39
▸ SLC6A3 Q01959 2/20 0.39
▸ CLPP Q16740 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3997201 0.89 TACR1 (0.52) SIGMAR1TACR1SLC6A2SLC6A4SLC6A3
SCHEMBL1617419 0.79 TACR1 (0.50) SIGMAR1TACR1DRD4SLC6A2SLC6A4
SCHEMBL6440459 0.76 TACR1 (0.64) SIGMAR1TACR1DRD4
SCHEMBL1400959 0.76 TACR1 (0.61) SIGMAR1TACR1
SCHEMBL3902021 0.76 TACR1 (0.54) SIGMAR1TACR1
SCHEMBL6439506 0.73 TACR1 (0.54) SIGMAR1TACR1DRD4
SCHEMBL6440867 0.73 TACR1 (0.65) SIGMAR1TACR1DRD4
SCHEMBL1617423 0.71 TACR1 (0.56) SIGMAR1TACR1
Bromide SCHEMBL3663120 0.71 TACR1 (0.42) SIGMAR1TACR1DRD4SLC6A2SLC6A4
SCHEMBL10918817 0.69 SIGMAR1 (0.68) SIGMAR1DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1360184-A1 PIPERIDINEE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2003-11-12 — — EP disclosed
WO-2002062784-A1 PIPERIDINEE DERIVATIVES AS NEUROKININ 1 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2002-08-15 — — WO disclosed