Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.58 |
| ▸ | ACP1 | P24666 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773802 | 0.84 | NPY5R (0.49) | ACHELMNACYP3A4CHRM1CYP1A2 | |
| Minaprine SCHEMBL49371 | 0.77 | ACHE (1.00) | ACHELMNACYP3A4CHRM1CYP1A2 | |
| Minaprine SCHEMBL124092 | 0.76 | CYP3A4 (1.00) | ACHELMNACYP3A4CHRM1CYP1A2 | |
| Minaprine SCHEMBL124094 | 0.76 | CYP3A4 (1.00) | ACHELMNACYP3A4CHRM1CYP1A2 | |
| SCHEMBL5773980 | 0.76 | NPY5R (0.55) | LMNATDP1NPY5RALOX15HSD17B10 | |
| SCHEMBL8126898 | 0.76 | IGF1R (0.39) | LMNANPY5RHSD17B10 | |
| SCHEMBL8115271 | 0.75 | GBA1 (0.40) | CYP3A4CYP2D6CNR1NPY5R | |
| Minaprine SCHEMBL124093 | 0.75 | ACHE (0.95) | ACHELMNACYP3A4CHRM1CYP1A2 | |
| Hydrochloric Acid SCHEMBL7184439 | 0.74 | GBA1 (0.40) | CYP3A4CYP2D6CNR1NPY5R | |
| Hydrochloric Acid SCHEMBL9013434 | 0.74 | CYP3A4 (0.62) | ACHELMNACYP3A4CHRM1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |