Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185729 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1GAAPIM1PRKCQ | |
| SCHEMBL8250121 | 0.92 | KDM4E (0.53) | KDM4EALDH1A1GAAIRAK4ALOX15 | |
| SCHEMBL27437365 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1GAAPIM1IRAK4 | |
| SCHEMBL7182013 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1GAAPIM1IRAK4 | |
| SCHEMBL29673232 | 0.86 | KDM4E (0.51) | KDM4EALDH1A1GAAPIM1IRAK4 | |
| SCHEMBL7187273 | 0.85 | KDM4E (0.54) | KDM4EALDH1A1GAAPIM1IRAK4 | |
| SCHEMBL6644188 | 0.85 | KDM4E (0.54) | KDM4EALDH1A1GAAPIM1IRAK4 | |
| SCHEMBL16444870 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1GAAIRAK4ALOX15 | |
| SCHEMBL16444868 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1GAAIRAK4ALOX15 | |
| SCHEMBL7178365 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1GAAIRAK4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204375-B1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | REVIRAL LTD (GB) | 2019-02-13 | — | — | EP | disclosed |
| US-10106539-B2 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) | ReViral Limited (GB) | 2018-10-23 | — | — | US | disclosed |
| US-20170305908-A1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | ReViral Limited (GB) | 2017-10-26 | — | — | US | disclosed |
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305908-A1 | SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV) | NR3C2, SAV1, ACE2 | KDM4E 4148/4885ALDH1A1 1371/4885GAA 4492/4885 |
| US-10106539-B2 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) | SPTBN1, NR3C2, SPNS2 | KDM4E 4216/4885ALDH1A1 1325/4885GAA 4434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.