Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.48 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 7/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.42 |
| ▸ | LPAR4 | Q99677 | 2/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027151 | 1.00 | SMPD1 (0.48) | SMPD1LPAR3LPAR1LPAR2ENPP2 | |
| SCHEMBL7180089 | 1.00 | SMPD1 (0.48) | SMPD1LPAR3LPAR1LPAR2ENPP2 | |
| SCHEMBL9711433 | 1.00 | SMPD1 (0.48) | SMPD1LPAR3LPAR1LPAR2ENPP2 | |
| SCHEMBL9026274 | 1.00 | SMPD1 (0.48) | SMPD1LPAR3LPAR1LPAR2ENPP2 | |
| SCHEMBL7182172 | 0.92 | SMPD1 (0.56) | SMPD1LPAR3LPAR1LPAR2PTPN1 | |
| SCHEMBL7192780 | 0.92 | SMPD1 (0.56) | SMPD1LPAR3LPAR1LPAR2PTPN1 | |
| SCHEMBL7183671 | 0.92 | SMPD1 (0.56) | SMPD1LPAR3LPAR1LPAR2PTPN1 | |
| SCHEMBL9026174 | 0.91 | SMPD1 (0.49) | SMPD1LPAR3LPAR1LPAR2ENPP2 | |
| SCHEMBL7185533 | 0.91 | SMPD1 (0.49) | SMPD1LPAR3LPAR1LPAR2ENPP2 | |
| SCHEMBL9130340 | 0.91 | SMPD1 (0.49) | SMPD1LPAR3LPAR1LPAR2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506393-B2 | Administering phosphocholine compound; leishmaniasis treatment | ZENTARIS AG (DE) | 2003-01-14 | — | — | US | disclosed |
| US-20010008885-A1 | Methods of treating protozoal diseases | MAX-PLANCK-GESSELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E. V. | 2001-07-19 | — | — | US | disclosed |
| US-6254879-B1 | QUATERNARIUMAMINOETHYLPHOSPHATES | Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. (DE) | 2001-07-03 | — | — | US | disclosed |
| US-5980915-A | ADMINISTERING AN ANTIPROTOZOA AGENT | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN (DE) | 1999-11-09 | — | — | US | disclosed |
| EP-0534445-B1 | Process for the preparation of a medicament for oral or topical administration in the treatment of leishmaniasis | MAX PLANCK GESELLSCHAFT (DE) | 1999-03-24 | — | — | EP | disclosed |
| EP-0534445-A1 | Process for the preparation of a medicament for oral or topical administration in the treatment of leishmaniasis | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1993-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010008885-A1 | Methods of treating protozoal diseases | HRH2, HRH1, HRH4 | SMPD1 300/4885LPAR3 141/4885LPAR1 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.