Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 7/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.68 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 2/20 | 0.60 |
| ▸ | CTSB | P07858 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097175 | 1.00 | TNFRSF1A (0.80) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL7099958 | 0.90 | ABCG2 (0.82) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL3215700 | 0.89 | TNFRSF1A (1.00) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL3215707 | 0.89 | TNFRSF1A (1.00) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL30674925 | 0.89 | TNFRSF1A (1.00) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL30383266 | 0.89 | TNFRSF1A (1.00) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL7097770 | 0.86 | MAPT (0.71) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL29600833 | 0.85 | TNFRSF1A (0.86) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL7180313 | 0.85 | TNFRSF1A (0.86) | TNFRSF1AMAPTLMNAHPGDALDH1A1 | |
| SCHEMBL7180309 | 0.85 | TNFRSF1A (0.86) | TNFRSF1AMAPTLMNAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6603046-B1 | The invention is drawn to novel bis-aromatic a, beta -unsaturated ketones. The compounds are useful in the treatment and prophylaxis of diseases caused by parasites or bacteria. | LICA PHARMACEUTICALS A/S (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-0634927-B1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES, OR BACTERIA | LICA PHARMACEUTICALS AS (DK) | 2001-07-04 | — | — | EP | disclosed |
| US-5985935-A | PARASITICIDES OR BACTERICIDES | STATENS SERUMINSTITUT (DK) | 1999-11-16 | — | — | US | disclosed |
| EP-0634927-A1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES, OR BACTERIA | STATENS SERUMINSTITUT (DK) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993017671-A1 | TREATMENT AND PROPHYLAXIS OF DISEASES CAUSED BY PARASITES, OR BACTERIA | STATENS SERUMINSTITUT (DK) | 1993-09-16 | — | — | WO | disclosed |