Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | PEPD | P12955 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5612384 | 0.96 | ALDH1A1 (0.57) | ALDH1A1CA1CA2CA9CES2 | |
| Bicarbonate SCHEMBL11072356 | 0.92 | ALDH1A1 (0.61) | ALDH1A1CA1CA2CA9CES2 | |
| Bicarbonate SCHEMBL10581815 | 0.89 | ALDH1A1 (0.57) | ALDH1A1CA1CA2CA9CES2 | |
| Bicarbonate SCHEMBL7025736 | 0.89 | ALDH1A1 (0.57) | ALDH1A1CA1CA2CA9CES2 | |
| Biphenyl SCHEMBL2169497 | 0.89 | ALDH1A1 (0.57) | ALDH1A1CA1CA2CA9CES2 | |
| Bicarbonate SCHEMBL10775900 | 0.89 | ALDH1A1 (0.57) | ALDH1A1CA1CA2CA9CES2 | |
| Bicarbonate SCHEMBL7194555 | 0.86 | ALDH1A1 (0.35) | ALDH1A1CA1CA2CA9CES2 | |
| Hydrogen Peroxide SCHEMBL296435 | 0.79 | ALDH1A1 (0.80) | ALDH1A1CA1CA2CES2CES1 | |
| Hydrogen Peroxide SCHEMBL2592699 | 0.79 | ALDH1A1 (0.80) | ALDH1A1CA1CA2CES2CES1 | |
| Acetic Acid SCHEMBL28848294 | 0.79 | ALDH1A1 (0.53) | ALDH1A1CES2CES1HSD11B1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6586154-B1 | Photoresist polymer of following formula 1, and a photoresist composition comprising photoresist composition has excellent transparency in deep ultraviolet region, etching resistance and heat resistance, and can form a good pattern without | HYUNDAI ELECTRONICS INDUSTRIES CO., LTD. (KR) | 2003-07-01 | — | — | US | disclosed |