Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7186411 | 1.00 | MAPT (0.53) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL30369816 | 0.93 | MAPT (0.60) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL7182913 | 0.87 | MAPT (0.69) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL9396486 | 0.86 | MAPT (0.68) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL6941586 | 0.81 | MAPT (0.58) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL6941409 | 0.81 | MAPT (0.58) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL1594377 | 0.81 | MAPT (0.54) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL6941411 | 0.81 | MAPT (0.58) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL6940663 | 0.78 | MAPT (0.52) | MAPTALDH1A1LMNACRHBPCRHR2 | |
| SCHEMBL14417267 | 0.78 | MAPT (0.55) | MAPTALDH1A1LMNACRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |