Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CRHBP | P24387 | 1/20 | 0.69 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9396486 | 0.98 | MAPT (0.68) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL30369816 | 0.94 | MAPT (0.60) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL7186411 | 0.87 | MAPT (0.53) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL7186417 | 0.87 | MAPT (0.53) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL1594377 | 0.85 | MAPT (0.54) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL23786250 | 0.82 | MAPT (0.69) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL8607686 | 0.82 | MAPT (0.69) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL28246789 | 0.82 | MAPT (1.00) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL14417267 | 0.82 | MAPT (0.55) | MAPTLMNAALDH1A1CRHBPCRHR2 | |
| SCHEMBL14410275 | 0.82 | MAPT (0.51) | MAPTLMNAALDH1A1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |