Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3295740 | 0.81 | TDP1 (0.52) | TDP1GAAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7180995 | 0.79 | MMP1 (0.50) | TSHRLCKMMP1MMP2MMP9 | |
| SCHEMBL9591612 | 0.77 | TDP1 (0.56) | TSHRTDP1GAAHSD17B10GRIN2D | |
| SCHEMBL2097650 | 0.76 | TDP1 (0.65) | TSHRTDP1MGAMGAASI | |
| SCHEMBL18304527 | 0.73 | NPC1 (0.54) | TSHRTTRLCKMMP1MMP2 | |
| SCHEMBL18304525 | 0.73 | NPC1 (0.54) | TSHRTTRLCKMMP1MMP2 | |
| SCHEMBL8967713 | 0.73 | LCK (0.67) | TSHRLCKMMP1MMP2MMP9 | |
| SCHEMBL2096364 | 0.73 | TDP1 (0.52) | TSHRTDP1MAOBGAAGRIN2D | |
| SCHEMBL8967718 | 0.73 | LCK (0.67) | TSHRLCKMMP1MMP2MMP9 | |
| SCHEMBL4701093 | 0.72 | LCK (0.64) | TSHRLCKMMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576664-B1 | 1-amido-2-hydroxy-substituted-indanes; suppressing production of tumor necrosis factor | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-06-10 | — | — | US | disclosed |