Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 20/20 | 0.74 |
| ▸ | AVPR1A | P37288 | 20/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL717387 | 1.00 | AVPR2 (0.74) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL807939 | 0.93 | AVPR2 (0.70) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL715845 | 0.93 | AVPR2 (0.73) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL460819 | 0.93 | AVPR2 (0.73) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL385140 | 0.93 | AVPR2 (0.73) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL716534 | 0.93 | AVPR2 (0.73) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL462943 | 0.93 | AVPR2 (0.73) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL4502013 | 0.92 | AVPR2 (0.76) | AVPR2AVPR1ASLC6A2OXTROPRK1 | |
| SCHEMBL6915489 | 0.91 | AVPR2 (0.71) | AVPR2AVPR1A | |
| SCHEMBL414412 | 0.90 | AVPR2 (0.74) | AVPR2AVPR1ASLC6A2OXTROPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408754-B1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF THE VASOPRESSIN RECEPTOR FOR THE TREATMENT OF CARDIAC INSUFFICIENCY | BAYER IP GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| EP-2408754-B1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF THE VASOPRESSIN RECEPTOR FOR THE TREATMENT OF CARDIAC INSUFFICIENCY | BAYER IP GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-20120053218-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN-RECEPTOR INHIBITORS FOR TREATING CARDIAC INSUFFICIENCY | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-01 | — | — | US | disclosed |
| US-20120053218-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN-RECEPTOR INHIBITORS FOR TREATING CARDIAC INSUFFICIENCY | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-01 | — | — | US | disclosed |
| US-20120053218-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN-RECEPTOR INHIBITORS FOR TREATING CARDIAC INSUFFICIENCY | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053218-A1 | TRIAZOLE DERIVATIVES AS VASOPRESSIN-RECEPTOR INHIBITORS FOR TREATING CARDIAC INSUFFICIENCY | AVPR2, AVPR1B, AVPR1A | AVPR2 1/4885AVPR1A 3/4885SLC6A2 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.