Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.45 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.33 |
| ▸ | KDM6B | O15054 | 2/20 | 0.33 |
| ▸ | KDM5C | P41229 | 2/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL7174556 | 0.91 | SLC22A6 (0.50) | LMNAMAPK1MAPTCAMK2ASLC22A6 | |
| SCHEMBL44488 | 0.89 | — | — | |
| SCHEMBL6009741 | 0.87 | MAPT (0.40) | MAPK1MAPTOR51E2MGLLFAAH | |
| Bicarbonate SCHEMBL3335342 | 0.87 | MAPT (0.40) | MAPK1MAPTOR51E2MGLLFAAH | |
| SCHEMBL5030994 | 0.87 | MAPT (0.40) | MAPK1MAPTOR51E2MGLLFAAH | |
| SCHEMBL9800955 | 0.86 | TET2 (0.39) | LMNAEGLN1ALKBH5SUCNR1MAPT | |
| SCHEMBL542358 | 0.83 | MAPT (0.53) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Alcohol SCHEMBL20504372 | 0.82 | MAPT (0.47) | MAPK1MAPTOR51E2TSHRFAAH | |
| Water SCHEMBL9474377 | 0.81 | MAPT (0.52) | LMNAEGLN1ALKBH5SUCNR1MAPK1 | |
| Oxirane SCHEMBL23581829 | 0.78 | MAPT (0.35) | MAPK1MAPTPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129120-B1 | MODIFIED POLYISOCYANATES | RHODIA CHIMIE SA (FR) | 2003-12-10 | — | — | EP | claimed |