SCHEMBL7186932

SCHEMBL7186932

CC(=O)Nc1ccccc1/C=C\C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.55
CYP1A2 P05177 1/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
NFKB1 P19838 1/20 0.53
CA4 P22748 1/20 0.53
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
POLB P06746 1/20 0.49
MAPT P10636 5/20 0.46
HTT P42858 1/20 0.46
KDM4E B2RXH2 2/20 0.46
AKR1C3 P42330 2/20 0.46
AKR1C2 P52895 2/20 0.46
HDAC3 O15379 1/20 0.46
TNKS O95271 1/20 0.46
HDAC4 P56524 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1881512 1.00 CYP2C19 (0.55) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL2551111 1.00 CYP2C19 (0.55) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
Methyl Alcohol SCHEMBL8740660 0.98 CYP2C19 (0.54) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
Methyl Alcohol SCHEMBL8740648 0.98 CYP2C19 (0.54) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
Alcohol SCHEMBL8740663 0.94 CYP2C19 (0.50) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
Alcohol SCHEMBL8740664 0.94 CYP2C19 (0.50) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL27822396 0.86 CA1 (0.56) CYP2C9CA1CA2NFKB1CA4
SCHEMBL11110869 0.85 ALDH1A1 (0.46) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL11110867 0.85 ALDH1A1 (0.46) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL27415289 0.85 CYP2C19 (0.54) CYP2C19CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113373466-B Electrochemical synthesis method of beta-acetaminocarbonyl compound 安徽科技学院 2023-07-21 CN disclosed
US-20230114794-A1 METAL COMPLEX, INTERMEDIATE, AND PREPARATION METHOD AND APPLICATION THEREOF SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) 2023-04-13 US disclosed
CN-111018918-B Metal complex, intermediate, preparation method and application thereof 中国科学院上海有机化学研究所 2022-10-04 CN disclosed
CN-113373466-A Electrochemical synthesis method of beta-acetaminocarbonyl compound 安徽科技学院 2021-09-10 CN disclosed
EP-3865494-A1 METAL COMPLEX, INTERMEDIATE, AND PREPARATION METHOD AND APPLICATION THEREOF Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CN) 2021-08-18 EP disclosed
EP-3271325-B1 PROCESS OF PRODUCTION OF (S) -METOLACHLOR ASCENZA AGRO S A (PT) 2020-12-02 EP disclosed
US-6583305-B1 Catalysts for enantioselective hydrogenation, hydroboration or 1,4 addition of olefins, ketones and imines STUDIENGESELLSCHAFT KOHLE MBH (DE) 2003-06-24 US disclosed
US-5990318-A Soluble polyester-supported chiral phosphines THE HONG KONG POLYTECHNIC UNIVERSITY (HK) 1999-11-23 US disclosed
US-5952527-A A COMPLEX OF TRANSITIONAL METAL COMPOUND, CYCLOOCTADIENE OR CYCLOPENTADIENE AND 2,2-BIS/DIPHENYLPHOSPHINOAMINO/-5,5',6,6'7,7',8,8'-OCTAHYDRO-1 ,1'-BINAPHTHYL COMPOUND; USED AS HYDROGENATION CATALYST THE HONG KONG POLYTECHNIC UNIVERSITY (HK) 1999-09-14 US disclosed
US-5919981-A USING HYDROGENATION 1,1*-BINAPHTHYL-2,2*-DIAMINE AS CHEMICAL INTERMEDIATE THE HONG KONG POLYTECHNIC UNIVERSITY (HK) 1999-07-06 US disclosed
EP-0564588-A1 HEXA- AND HEPTAPEPTIDE ANAPHYLATOXIN-RECEPTOR LIGANDS. ABBOTT LAB (US) 1993-10-13 EP disclosed
US-5252751-A Diphosphines containing silane groups, immobilised diphosphines and the use thereof as hydrogenation catalysts CIBA-GEIGY CORPORATION (US) 1993-10-12 US disclosed
US-5244857-A DIPHOSPHINES CONTAINING SILANE GROUPS, IMMOBILISE DIPHOSPHINES AND THE USE THEREOF AS HYDROGENATION CATALYSTS CIBA-GEIGY CORPORATION (US) 1993-09-14 US disclosed
US-5223485-A Oligopeptides as antiinflammatory agents ABBOTT LABORATORIES (US) 1993-06-29 US disclosed
WO-1992011858-A1 HEXA- AND HEPTAPEPTIDE ANAPHYLATOXIN-RECEPTOR LIGANDS ABBOTT LABORATORIES (US) 1992-07-23 WO disclosed
EP-0456758-A1 ANAPHYLATOXIN-RECEPTOR LIGANDS ABBOTT LABORATORIES (US) 1991-11-21 EP disclosed
WO-1990009162-A2 ANAPHYLATOXIN-RECEPTOR LIGANDS ABBOTT LABORATORIES (US) 1990-08-23 WO disclosed
US-4438033-A Steroidal chiral phosphines, methods for their preparation, catalytic systems containing them and catalytic processes in which they are used CONSIGLIO NAZIONALE DELLE RICERCHE (IT) 1984-03-20 US disclosed
US-4424312-A COPOLYMERIZING N-ACRYLOYL-4-(DIPHENYLPHOSPHINO)-2--(DIPHENYLPHOSPHINOMETHYL)PYRROLIDINE, RHODIUM COMPLEX POLYMER SCIENCES CORPORATION (US) 1984-01-03 US disclosed
EP-0081149-A1 New steroidal chiral phosphines, methods for their preparation, catalytic systems containing them and catalytic processes in which they are used CONSIGLIO NAZIONALE DELLE RICERCHE (IT) 1983-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230114794-A1 METAL COMPLEX, INTERMEDIATE, AND PREPARATION METHOD AND APPLICATION THEREOF AP2M1, AP3M1, AP1M1 CYP2C19 238/4885CYP1A2 152/4885CYP3A4 498/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.