Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 12/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 4/20 | 0.40 |
| ▸ | FDPS | P14324 | 3/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | PGK2 | P07205 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187785 | 0.73 | PTPN1 (0.54) | PTPN1PTPN2PTPN6PTPN11PTPRC | |
| SCHEMBL7596773 | 0.72 | PTPN1 (0.45) | PTPN1PTPN2PTPN5PGK1PGK2 | |
| SCHEMBL7194765 | 0.72 | PTPN1 (0.46) | PTPN1PTPN2PGK1PGK2 | |
| SCHEMBL7169125 | 0.72 | PTPN1 (0.55) | PTPN1PTPN2PTPN6PTPN11PTPRC | |
| SCHEMBL5395213 | 0.72 | PTPN1 (0.50) | PTPN1PTPN2PTPN6PTPN11PTPRC | |
| SCHEMBL7197496 | 0.72 | PTPN1 (0.44) | PTPN1PTPN2PTPN6PTPN11PTPRC | |
| SCHEMBL7595769 | 0.72 | PTPN1 (0.45) | PTPN1PTPN2PGK1PGK2 | |
| SCHEMBL3735747 | 0.71 | PGK1 (0.52) | PTPN1PTPN2PGK1PGK2 | |
| SCHEMBL27715888 | 0.71 | PTPN1 (0.47) | PTPN1PTPN2PTPRC | |
| SCHEMBL7592972 | 0.71 | PTPN1 (0.49) | PTPN1PTPN2PTPRCPTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |