Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | HTR1D | P28221 | 2/20 | 0.61 |
| ▸ | HTR1B | P28222 | 2/20 | 0.61 |
| ▸ | HTR1F | P30939 | 2/20 | 0.61 |
| ▸ | HTR7 | P34969 | 2/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3622437 | 0.84 | HTR6 (0.63) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3612612 | 0.81 | HTR6 (0.59) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL13120192 | 0.81 | HTR6 (0.59) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4783302 | 0.81 | HTR6 (0.62) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL27642787 | 0.80 | HTR6 (0.58) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3622212 | 0.78 | HTR6 (0.59) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3611374 | 0.78 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Hydrochloric Acid SCHEMBL3624923 | 0.77 | HTR6 (0.78) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL13120194 | 0.76 | HTR6 (0.64) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3624867 | 0.76 | HTR6 (0.64) | HTR6HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353904-A1 | 1-ARYL-OR 1-ALKYLSULFONYLBENZAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002059088-A1 | 1-ARYL-OR 1-ALKYLSULFONYLBENZAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-08-01 | — | — | WO | disclosed |