Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.48 |
| ▸ | PCNA | P12004 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189109 | 0.94 | ESR1 (0.48) | ESR1FFAR1FFAR4ESR2ALDH1A1 | |
| SCHEMBL7187874 | 0.94 | ESR1 (0.55) | ESR1FFAR1FFAR4ESR2PCNA | |
| SCHEMBL7187252 | 0.94 | ESR1 (0.62) | ESR1FFAR1FFAR4ESR2PCNA | |
| SCHEMBL7183632 | 0.93 | FFAR1 (0.52) | ESR1FFAR1FFAR4KDM4EALDH1A1 | |
| SCHEMBL7185982 | 0.90 | FFAR1 (0.50) | ESR1FFAR1FFAR4ESR2 | |
| SCHEMBL7189366 | 0.90 | ESR1 (0.55) | ESR1FFAR1FFAR4ESR2PCNA | |
| SCHEMBL7195082 | 0.90 | ESR1 (0.56) | ESR1FFAR1FFAR4ESR2PCNA | |
| SCHEMBL7183659 | 0.87 | ESR1 (0.54) | ESR1FFAR4ESR2PCNA | |
| SCHEMBL7181091 | 0.87 | ESR1 (0.48) | ESR1FFAR1FFAR4ESR2 | |
| SCHEMBL7183696 | 0.87 | FFAR1 (0.51) | ESR1FFAR1FFAR4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |