Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.52 |
| ▸ | PCNA | P12004 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189109 | 0.94 | ESR1 (0.48) | ESR1ESR2FFAR4 | |
| SCHEMBL7187252 | 0.93 | ESR1 (0.62) | ESR1ESR2PCNAFFAR4 | |
| SCHEMBL7191690 | 0.91 | ESR1 (0.54) | ESR1ESR2PCNAFFAR4CYP1A2 | |
| SCHEMBL7187548 | 0.88 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL7195082 | 0.87 | ESR1 (0.56) | ESR1ESR2PCNAFFAR4 | |
| SCHEMBL7188059 | 0.87 | ESR1 (0.55) | ESR1ESR2PCNAFFAR4 | |
| SCHEMBL7189366 | 0.87 | ESR1 (0.55) | ESR1ESR2PCNAFFAR4 | |
| SCHEMBL7188433 | 0.87 | ESR1 (0.48) | ESR1ESR2ALDH2MAOAMAOB | |
| SCHEMBL7187213 | 0.86 | FFAR4 (0.47) | ESR1ESR2FFAR4CYP1A2MAOA | |
| SCHEMBL7187874 | 0.85 | ESR1 (0.55) | ESR1ESR2PCNAFFAR4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |