Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.41 |
| ▸ | PAM | P19021 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 7/20 | 0.40 |
| ▸ | THRB | P10828 | 7/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188316 | 1.00 | ESR1 (0.41) | ESR1ESR2PAMTHRATHRB | |
| SCHEMBL7185012 | 0.89 | ESR1 (0.50) | ESR1ESR2ABCG2 | |
| SCHEMBL7185015 | 0.89 | ESR1 (0.50) | ESR1ESR2ABCG2 | |
| SCHEMBL7184010 | 0.89 | ESR1 (0.43) | ESR1ESR2PAMABCG2 | |
| SCHEMBL7184005 | 0.89 | ESR1 (0.43) | ESR1ESR2PAMABCG2 | |
| SCHEMBL7189412 | 0.87 | ESR1 (0.48) | ESR1ESR2PAM | |
| SCHEMBL7189415 | 0.87 | ESR1 (0.48) | ESR1ESR2PAM | |
| SCHEMBL7181375 | 0.84 | ESR1 (0.50) | ESR1ESR2PAMABCG2 | |
| SCHEMBL7181373 | 0.84 | ESR1 (0.50) | ESR1ESR2PAMABCG2 | |
| SCHEMBL7189157 | 0.83 | ESR1 (0.44) | ESR1ESR2PAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-0835867-A1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |