Sugi Predict

Sugi Predict / Compounds / SCHEMBL7188367

SCHEMBL7188367

SCHEMBL7188367

COc1cc(C)cc(OC)c1P(=O)(C(=O)c1ccccc1)C(=O)c1c(C(F)(F)F)cccc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 2/20 0.40
▸ MAPT P10636 3/20 0.39
▸ NPSR1 Q6W5P4 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ ALOX12 P18054 1/20 0.39
▸ SLC6A9 P48067 1/20 0.39
▸ EPHX1 P07099 1/20 0.38
▸ MRGPRX4 Q96LA9 2/20 0.38
▸ KCNK3 O14649 2/20 0.38
▸ KCNK9 Q9NPC2 2/20 0.38
▸ EPHX2 P34913 1/20 0.38
▸ LMNA P02545 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ RECQL P46063 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ ATM Q13315 2/20 0.36
▸ GAA P10253 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180674 0.86 CA12 (0.44) MAPTALDH1A1EPHX1KCNK3KCNK9
SCHEMBL7188198 0.84 EPHX1 (0.42) MAPTEPHX1KCNK3KCNK9LMNA
SCHEMBL7188372 0.84 MAOB (0.39) MAOBMAPTNPSR1SLC6A9LMNA
SCHEMBL7189010 0.83 SLC6A9 (0.41) MAOBMAPTSLC6A9MRGPRX4LMNA
SCHEMBL7177761 0.83 EPHX1 (0.43) MAPTEPHX1LMNAKDM4ECYP3A4
SCHEMBL7187560 0.83 ATM (0.41) MAPTNPSR1ALDH1A1SLC6A9LMNA
SCHEMBL7177644 0.82 EPHX1 (0.40) MAPTALDH1A1EPHX1LMNAKDM4E
SCHEMBL7175520 0.81 EPHX1 (0.41) MAOBMAPTALDH1A1EPHX1LMNA
SCHEMBL7181915 0.81 MAPT (0.41) MAPTALDH1A1SLC6A9LMNAKDM4E
SCHEMBL7190538 0.81 HPGD (0.39) MAPTALDH1A1SLC6A9EPHX1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 MAOB 4189/4885MAPT 4870/4885NPSR1 2669/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 MAOB 4319/4885MAPT 4859/4885NPSR1 3007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.