Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 10/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187905 | 0.94 | ESR1 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL7191960 | 0.93 | CYP3A4 (0.59) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL7195062 | 0.88 | ESR1 (0.53) | ESR1ESR2 | |
| SCHEMBL7185785 | 0.87 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL7194900 | 0.87 | ESR1 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL7188150 | 0.85 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL7189223 | 0.85 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL7189216 | 0.85 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL7193070 | 0.84 | ESR1 (0.53) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 | |
| SCHEMBL7184090 | 0.84 | CYP3A4 (0.52) | CYP1A2CYP3A4CYP2D6CYP2C9HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | claimed |