Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21310999 | 1.00 | ALOX15 (0.60) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL7188685 | 1.00 | ALOX15 (0.60) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL23971034 | 0.94 | ALOX15 (0.66) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL27218080 | 0.89 | ALOX15 (0.74) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL5836935 | 0.89 | ALOX15 (0.70) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL5065680 | 0.88 | ALOX15 (0.77) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL2028039 | 0.87 | ALOX15 (0.80) | ALOX15GAARAB9APTGER4 | |
| SCHEMBL2028037 | 0.87 | ALOX15 (0.80) | ALOX15GAARAB9APTGER4 | |
| SCHEMBL7190438 | 0.86 | PRKCI (0.56) | ALOX15MAPTKDM4EALDH1A1GAA | |
| SCHEMBL21311001 | 0.85 | ALOX15 (0.59) | ALOX15MAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |