Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382418 | 0.81 | MGAM (0.60) | MGAMCFTRHDAC1HDAC3HDAC6 | |
| SCHEMBL3380927 | 0.78 | HDAC1 (0.65) | MGAMHDAC1HDAC3HDAC6HDAC2 | |
| SCHEMBL9360308 | 0.77 | MGAM (0.58) | MGAMCFTRHDAC1HDAC3HDAC2 | |
| SCHEMBL9361658 | 0.74 | MGAM (0.61) | MGAMCFTRHDAC1HDAC3HDAC6 | |
| SCHEMBL7100632 | 0.74 | MGAM (0.61) | MGAMCFTRHDAC1HDAC3HDAC6 | |
| SCHEMBL7185135 | 0.74 | HDAC1 (0.59) | HDAC1HDAC8 | |
| SCHEMBL529904 | 0.73 | MGAM (0.65) | MGAMCFTRHDAC1HDAC3DPP4 | |
| SCHEMBL7173927 | 0.72 | CTNNB1 (0.46) | HDAC1HDAC3HDAC6HDAC2HDAC8 | |
| SCHEMBL1061067 | 0.72 | HDAC1 (0.43) | MGAMHDAC1HDAC3HDAC6HDAC2 | |
| SCHEMBL29362497 | 0.71 | MGAM (0.71) | MGAMCFTRDPP4BCAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280764-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001070675-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-09-27 | — | — | WO | disclosed |