Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 3/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7189178 | 1.00 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7190238 | 0.95 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7190244 | 0.95 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7187067 | 0.93 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7191715 | 0.92 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DDPP4 | |
| SCHEMBL7194645 | 0.90 | AR (0.44) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7194643 | 0.90 | AR (0.44) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7190358 | 0.87 | CYP1A1 (0.47) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7190363 | 0.87 | CYP1A1 (0.47) | PDE4APDE4BPDE4CPDE4DCYP1A1 | |
| SCHEMBL7194861 | 0.87 | AR (0.51) | PDE4APDE4BPDE4CPDE4DCYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | STATENS SERUM INSTITUTE (DK) | 2003-04-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | AKR1C3, AKR1C1, AKR1A1 | PDE4A 3419/4885PDE4B 3413/4885PDE4C 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.