Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189317

SCHEMBL7189317

SCHEMBL7189317

COc1c(Cl)c(C(=O)c2ccccc2)cc(Cl)c1[PH](=O)C(=O)c1c(C)cc(C)c(C)c1C

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.34
▸ LMNA P02545 3/20 0.34
▸ HPGD P15428 3/20 0.34
▸ ALDH1A1 P00352 3/20 0.34
▸ MAPT P10636 3/20 0.34
▸ CYP1A2 P05177 2/20 0.34
▸ CYP2C19 P33261 2/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ HTT P42858 2/20 0.34
▸ MAPK1 P28482 2/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ PGR P06401 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ SLC6A2 P23975 1/20 0.34
▸ PDE4A P27815 1/20 0.34
▸ HRH1 P35367 1/20 0.34
▸ SLC6A3 Q01959 1/20 0.34
▸ PDE4D Q08499 1/20 0.34
▸ RECQL P46063 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189545 0.90 KMT2A (0.36) KMT2ALMNAHPGDALDH1A1MAPT
SCHEMBL7183278 0.89 MAPT (0.38) KMT2ALMNAHPGDALDH1A1MAPT
SCHEMBL7177974 0.88 TAS1R3 (0.34) LMNAHPGDALDH1A1MAPTCYP1A2
SCHEMBL7177494 0.88 TP53 (0.35) LMNAALDH1A1MAPTTP53ALOX15
SCHEMBL7178025 0.87 KMT2A (0.34) KMT2ALMNAHPGDALDH1A1MAPT
SCHEMBL7186758 0.87 KMT2A (0.38) KMT2ALMNAHPGDALDH1A1MAPT
SCHEMBL7187673 0.86 KMT2A (0.40) KMT2ALMNAHPGDALDH1A1MAPT
SCHEMBL7186628 0.84 MAPT (0.41) KMT2ALMNAHPGDMAPTCYP3A4
SCHEMBL7182791 0.84 TP53 (0.34) KMT2ALMNAHPGDALDH1A1MAPT
SCHEMBL7181463 0.82 HPGD (0.36) KMT2ALMNAHPGDALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMT2A 1586/4885LMNA 3241/4885HPGD 3983/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMT2A 956/4885LMNA 3247/4885HPGD 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.