Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29695661 | 0.87 | GSK3B (0.61) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL11654326 | 0.82 | HSF1 (0.59) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL1600402 | 0.76 | PIN1 (0.65) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL10810171 | 0.76 | GSK3B (0.58) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL2572184 | 0.76 | GSK3B (0.58) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL11834671 | 0.75 | GSK3B (0.65) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL12100934 | 0.74 | GSK3B (0.57) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL4400500 | 0.74 | GSK3B (0.39) | GSK3BGSK3AMAPK1ALDH1A1TDP1 | |
| SCHEMBL13730151 | 0.73 | GSK3B (0.56) | GSK3BPIN1GSK3AAURKAMAPK1 | |
| SCHEMBL1601194 | 0.73 | HSF1 (0.52) | GSK3BPIN1MAPK1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |