Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7178322 | 1.00 | GPR119 (0.54) | GPR119IRAK4PIK3CDALDH1A1USP30 | |
| SCHEMBL7178327 | 1.00 | GPR119 (0.54) | GPR119IRAK4PIK3CDALDH1A1USP30 | |
| SCHEMBL4438915 | 0.94 | GPR119 (0.61) | GPR119IRAK4ALDH1A1NPC1MAPT | |
| SCHEMBL6154205 | 0.88 | GPR119 (0.54) | GPR119IRAK4PIK3CDALDH1A1BRD4 | |
| SCHEMBL16876713 | 0.85 | GPR119 (0.58) | GPR119IRAK4ALDH1A1NPC1MAPT | |
| SCHEMBL7182933 | 0.84 | GPR119 (0.51) | GPR119IRAK4PIK3CDALDH1A1USP30 | |
| SCHEMBL7183947 | 0.84 | GPR119 (0.51) | GPR119IRAK4PIK3CDALDH1A1USP30 | |
| SCHEMBL7182925 | 0.84 | GPR119 (0.51) | GPR119IRAK4PIK3CDALDH1A1USP30 | |
| SCHEMBL16512911 | 0.84 | USP30 (0.50) | ALDH1A1USP30BRD4NPC1MAPT | |
| SCHEMBL28475988 | 0.83 | HDAC1 (0.47) | GPR119IRAK4HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |