Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9093649 | 1.00 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL950831 | 1.00 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL5892403 | 0.83 | KDM4E (0.63) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL6811019 | 0.82 | KDM4E (0.42) | KDM4ELMNAALDH1A1TDP1POLB | |
| SCHEMBL24004713 | 0.81 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL75505 | 0.81 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL900095 | 0.81 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL5431682 | 0.81 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL21705290 | 0.81 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 | |
| SCHEMBL16898630 | 0.81 | KDM4E (0.61) | KDM4ELMNATHRBEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019426-B1 | NOVEL A1 ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS | UNIV FLORIDA (US) | 2003-03-12 | — | — | EP | disclosed |