Sugi Predict

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Lithium

Lithium

SCHEMBL7189906

O=C(Pc1ccc(Oc2ccccc2)cc1Oc1ccccc1)c1c(Cl)cccc1Cl.[Li]

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMO O15229 1/20 0.42
▸ AKR1C3 P42330 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ THRB P10828 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ LMNA P02545 2/20 0.40
▸ MRGPRX4 Q96LA9 1/20 0.39
▸ DAGLA Q9Y4D2 2/20 0.39
▸ TLR8 Q9NR97 1/20 0.38
▸ TLR7 Q9NYK1 1/20 0.38
▸ DPP4 P27487 1/20 0.38
▸ STK39 Q9UEW8 1/20 0.38
▸ HDAC8 Q9BY41 2/20 0.38
▸ PPARG P37231 1/20 0.38
▸ PPARA Q07869 1/20 0.38
▸ PGR P06401 1/20 0.37
▸ MITF O75030 1/20 0.37
▸ POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7189899 0.97 KMO (0.42) KMOAKR1C3ALDH1A1THRBKMT2A
Lithium SCHEMBL7189155 0.93 KMT2A (0.41) ALDH1A1KMT2AL3MBTL1LMNAPGR
Lithium SCHEMBL7175039 0.93 KMT2A (0.38) KMOAKR1C3ALDH1A1THRBKMT2A
SCHEMBL7189149 0.91 KMT2A (0.41) ALDH1A1KMT2ALMNAPGRPOLB
SCHEMBL7175036 0.91 KMT2A (0.40) KMOAKR1C3ALDH1A1THRBKMT2A
Lithium SCHEMBL7175882 0.86 MEN1 (0.41) AKR1C3KMT2ALMNAHDAC8POLB
Lithium SCHEMBL7190200 0.85 MEN1 (0.44) AKR1C3ALDH1A1KMT2AL3MBTL1LMNA
SCHEMBL7175874 0.83 MEN1 (0.44) AKR1C3KMT2ALMNAHDAC8POLB
SCHEMBL7175548 0.83 PTGS1 (0.42) KMOAKR1C3KMT2ALMNADAGLA
Lithium SCHEMBL7181144 0.83 SCN8A (0.39) AKR1C3THRBHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMO 1201/4885AKR1C3 199/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMO 728/4885AKR1C3 209/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.