Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 15/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 5/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.47 |
| ▸ | PGK1 | P00558 | 3/20 | 0.47 |
| ▸ | PGK2 | P07205 | 3/20 | 0.47 |
| ▸ | PTPRB | P23467 | 3/20 | 0.43 |
| ▸ | PTPRC | P08575 | 2/20 | 0.43 |
| ▸ | CDC25A | P30304 | 1/20 | 0.43 |
| ▸ | EPM2A | O95278 | 1/20 | 0.40 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7188013 | 0.84 | PGK1 (0.64) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7188473 | 0.81 | PTPN1 (0.48) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7598742 | 0.81 | PTPN1 (0.54) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7598752 | 0.76 | PTPN1 (0.44) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7190900 | 0.76 | — | — | |
| SCHEMBL7189537 | 0.73 | PTPN1 (0.60) | PTPN1PTPN2PGK1PGK2PTPRC | |
| SCHEMBL7188019 | 0.73 | PGK1 (0.57) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL7188031 | 0.72 | PTPN1 (0.52) | PTPN1PTPN2PTPN6PTPN11PGK1 | |
| SCHEMBL28476733 | 0.72 | — | — | |
| SCHEMBL7193692 | 0.71 | PTPN1 (0.48) | PTPN1PTPN2PTPN6PTPN11PGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |