Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.49 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.49 |
| ▸ | SOX18 | P35713 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16898315 | 0.89 | CYP1A2 (0.73) | CYP1A2PDPK1HDAC1HDAC8FFAR1 | |
| SCHEMBL19612760 | 0.86 | HDAC1 (0.68) | CYP1A2PDPK1HDAC1HDAC8HCAR2 | |
| SCHEMBL9062915 | 0.86 | HDAC1 (0.68) | CYP1A2PDPK1HDAC1HDAC8HCAR2 | |
| SCHEMBL7332873 | 0.85 | CYP1A2 (0.66) | CYP1A2PDPK1HDAC1HDAC8FFAR1 | |
| SCHEMBL30403190 | 0.83 | CYP1A2 (0.80) | CYP1A2PDPK1HDAC1HDAC8FFAR1 | |
| SCHEMBL1217683 | 0.83 | CYP1A2 (0.80) | CYP1A2PDPK1HDAC1HDAC8FFAR1 | |
| SCHEMBL9404005 | 0.81 | CYP1A2 (0.62) | CYP1A2PDPK1HDAC1HDAC8FFAR1 | |
| SCHEMBL5236795 | 0.81 | CYP1A2 (0.68) | CYP1A2PDPK1HDAC1HDAC8FFAR1 | |
| SCHEMBL1137617 | 0.81 | CYP1A2 (0.62) | CYP1A2PDPK1HDAC1HDAC8FFAR1 | |
| Hydrochloric Acid SCHEMBL27401796 | 0.81 | CYP1A2 (0.77) | CYP1A2PDPK1HDAC1HDAC8FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966456-B1 | TAXOID REVERSAL AGENTS FOR DRUG-RESISTANCE IN CANCER CHEMOTHERAPY AND PHARMACEUTICAL COMPOSITIONS THEREOF | UNIV NEW YORK STATE RES FOUND (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-0966456-A4 | TAXOID REVERSAL AGENTS FOR DRUG-RESISTANCE IN CANCER CHEMOTHERAPY AND PHARMACEUTICAL COMPOSITIONS THEREOF | RES FOUNDATION OF (US) | 2000-07-26 | — | — | EP | disclosed |
| EP-0966456-A1 | TAXOID REVERSAL AGENTS FOR DRUG-RESISTANCE IN CANCER CHEMOTHERAPY AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1999-12-29 | — | — | EP | disclosed |
| US-5811452-A | ADMINISTERING WITH PACLITAXEL OR DOXORUBICIN | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1998-09-22 | — | — | US | disclosed |
| WO-1998030553-A1 | TAXOID REVERSAL AGENTS FOR DRUG-RESISTANCE IN CANCER CHEMOTHERAPY AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1998-07-16 | — | — | WO | disclosed |
| US-4565877-A | Naphthalene derivatives and method for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-21 | — | — | US | disclosed |
| EP-0107149-B1 | NOVEL NAPHTHALENE DERIVATIVES AND METHOD FOR PREPARATION THEREOF | Tanabe Seiyaku Co., Ltd. (JP) | 1985-10-16 | — | — | EP | disclosed |
| EP-0107149-A1 | Novel naphthalene derivatives and method for preparation thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1984-05-02 | — | — | EP | disclosed |
| US-4131644-A | TREATING POLYBUTADIENE WITH A LEWIS ACID AND A SULFUR MELT, CARBONIZING | UBE INDUSTRIES, INC. (JP) | 1978-12-26 | — | — | US | disclosed |
| US-4129704-A | Polymerization of vinyl monomers employing a diperoxyester mixture composition prepared by reacting dihydroperoxide and peroxyester forming carbonyl compounds | PENNWALT CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |
| US-4097408-A | FROM DIHYDOPEROXIDE AND CARBONYL COMPOUND, POLYMERIZATION CATALYSTS | PENNWALT CORPORATION (US) | 1978-06-27 | — | — | US | disclosed |