Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | NAAA | Q02083 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9062915 | 1.00 | HDAC1 (0.68) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL16898315 | 0.93 | CYP1A2 (0.73) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL7191582 | 0.86 | CYP1A2 (0.62) | HDAC1HDAC8CYP1A2HCAR2SIGMAR1 | |
| SCHEMBL10439755 | 0.85 | CYP1A2 (0.87) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL2536989 | 0.85 | CYP1A2 (0.87) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL8434872 | 0.85 | CYP1A2 (0.87) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL10439522 | 0.85 | CYP1A2 (0.87) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL10439619 | 0.85 | CYP1A2 (0.87) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL710798 | 0.85 | CYP1A2 (0.87) | HDAC1HDAC8CYP1A2NAAAHCAR2 | |
| SCHEMBL2107915 | 0.85 | CYP1A2 (0.87) | HDAC1HDAC8CYP1A2NAAAHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | XIAMEN UNIVERSITY (CN) | 2019-01-08 | — | — | US | disclosed |
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | XIAMEN UNIVERSITY (CN) | 2017-11-23 | — | — | US | disclosed |
| CN-107074788-A | Substituted heterocyclic derivatives, preparation method and application thereof | 厦门大学 | 2017-08-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334896-A1 | Substituted Heterocyclic Derivative, Preparation Method And Use Thereof | FAAH, NAAA, FAAH2 | HDAC1 317/4885HDAC8 522/4885CYP1A2 286/4885 |
| US-10174015-B2 | Substituted heterocyclic derivative, preparation method and use thereof | DHPS, CYP3A5, CYP3A4 | HDAC1 646/4885HDAC8 667/4885CYP1A2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.