Hydrocortisone Valerate

SCHEMBL7195472

CCCCC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C.C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone Valerate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	3/20	0.60

▸	HIF1A	Q16665	7/20	0.63

▸	KMT2A	Q03164	2/20	0.63

▸	NR3C2	P08235	8/20	0.62

▸	PGR	P06401	5/20	0.60

▸	AR	P10275	3/20	0.48

▸	CYP3A4	P08684	2/20	0.48

▸	ADORA3	P0DMS8	1/20	0.48

▸	CHRM1	P11229	1/20	0.47

▸	NR1I2	O75469	1/20	0.47

▸	HTR2B	P41595	1/20	0.47

▸	MAPT	P10636	2/20	0.45

▸	SMN1; SMN2	Q16637	2/20	0.45

▸	POLB	P06746	1/20	0.45

▸	GAA	P10253	1/20	0.45

▸	LMNA	P02545	1/20	0.45

▸	NPSR1	Q6W5P4	1/20	0.45

▸	CYP2C19	P33261	2/20	0.44

▸	HSD17B10	Q99714	2/20	0.44

▸	SHBG	P04278	1/20	0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Hydrocortisone Butyrate SCHEMBL8584180	0.82	NR3C2 (0.66)	HIF1AKMT2ANR3C2PGRNR3C1
SCHEMBL10939922	0.80	HIF1A (0.65)	HIF1AKMT2ANR3C2PGRNR3C1
SCHEMBL11360871	0.80	HIF1A (0.65)	HIF1AKMT2ANR3C2PGRNR3C1
Halobetasol Propionate SCHEMBL4633197	0.80	PGR (0.62)	HIF1AKMT2ANR3C2PGRNR3C1
Hydrocortisone Valerate SCHEMBL11356233	0.80	HIF1A (0.97)	HIF1AKMT2ANR3C2PGRNR3C1
Hydrocortisone Valerate SCHEMBL80603	0.80	HIF1A (1.00)	HIF1AKMT2ANR3C2PGRNR3C1
Hydrocortisone Valerate SCHEMBL290847	0.80	HIF1A (1.00)	HIF1AKMT2ANR3C2PGRNR3C1
Hydrocortisone Valerate SCHEMBL14339595	0.80	HIF1A (1.00)	HIF1AKMT2ANR3C2PGRNR3C1
Hydrocortisone Valerate SCHEMBL21111527	0.80	HIF1A (1.00)	HIF1AKMT2ANR3C2PGRNR3C1
Hydrocortisone Valerate SCHEMBL27891240	0.80	HIF1A (1.00)	HIF1AKMT2ANR3C2PGRNR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6511960-B2	Cromolyn for eye and ear infections	ALPHAMED PHARMACEUTICALS CORP	2003-01-28	—	—	US	disclosed
US-20020091100-A1	Cromolyn for eye and ear infections	ALPHAMED PHARMACEUTICALS CORPORATION	2002-07-11	—	—	US	disclosed