Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ATM | Q13315 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | JUN | P05412 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7196297 | 1.00 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL7188081 | 0.88 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL7188088 | 0.88 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL5137643 | 0.86 | MAOB (0.75) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL5137641 | 0.86 | MAOB (0.75) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL30504730 | 0.85 | ABCG2 (0.78) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL7096821 | 0.85 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL7194877 | 0.84 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL7194872 | 0.84 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DABCG2 | |
| SCHEMBL7096205 | 0.82 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | STATENS SERUM INSTITUTE (DK) | 2003-04-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030065039-A1 | Biologically active 1,3-bis-aromatic-prop-2-en-1-ones, 1,3-bis-aromatic-propan-1-ones, and 1,3-bis-aromatic-prop-2-yn-1-ones | AKR1C3, AKR1C1, AKR1A1 | PDE4A 3419/4885PDE4B 3413/4885PDE4C 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.