Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.60 |
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | FLT1 | P17948 | 3/20 | 0.57 |
| ▸ | FLT4 | P35916 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 2/20 | 0.57 |
| ▸ | KIF5B | P33176 | 2/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145040 | 0.85 | EGFR (0.58) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL6985569 | 0.85 | EGFR (0.56) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4427825 | 0.83 | EGFR (0.62) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4423483 | 0.83 | EGFR (0.62) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL5496194 | 0.83 | KDR (0.67) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL6980237 | 0.83 | KDR (0.53) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4690101 | 0.82 | KDR (0.65) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL7682090 | 0.82 | EGFR (0.60) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL6986555 | 0.82 | KDR (0.52) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4690075 | 0.81 | EGFR (0.64) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272185-A2 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001066099-A2 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2001-09-13 | — | — | WO | disclosed |