Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | EGFR | P00533 | 15/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | KIF5B | P33176 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986555 | 0.92 | KDR (0.52) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7145040 | 0.92 | EGFR (0.58) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5828196 | 0.88 | RAF1 (0.48) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5828194 | 0.88 | RAF1 (0.48) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL7091634 | 0.86 | KDR (0.54) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL6985569 | 0.86 | EGFR (0.56) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL6982367 | 0.84 | EGFR (0.55) | KDREGFRRET | |
| SCHEMBL7196859 | 0.83 | EGFR (0.60) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5496194 | 0.80 | KDR (0.67) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL5827926 | 0.80 | RAF1 (0.47) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |