SCHEMBL7196866

SCHEMBL7196866

CCCC(N)n1cnc2ncccc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.37
ASAH1 Q13510 1/20 0.34
ADA P00813 3/20 0.34
SLC6A2 P23975 1/20 0.33
LTA4H P09960 1/20 0.33
HRH4 Q9H3N8 1/20 0.33
SLC29A1 Q99808 1/20 0.32
CYP2D6 P10635 1/20 0.32
KCNE1 P15382 1/20 0.32
KCNA5 P22460 1/20 0.32
CYP2C9 P11712 1/20 0.32
IDO1 P14902 1/20 0.32
TLR8 Q9NR97 1/20 0.32
TLR7 Q9NYK1 1/20 0.32
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
HTR3E A5X5Y0 1/20 0.31
HTR3B O95264 1/20 0.31
HTR3A P46098 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21591572 0.88 HIF1A (0.39) HIF1AASAH1LTA4HCYP2D6KCNE1
SCHEMBL22606405 0.77 HIF1A (0.43) HIF1AASAH1ADA
SCHEMBL21311454 0.77 HIF1A (0.36) HIF1AASAH1ADALTA4HCYP2C9
SCHEMBL20664871 0.76 HIF1A (0.44) HIF1AASAH1LTA4HCYP2C9IDO1
SCHEMBL1106477 0.75 HIF1A (0.45) HIF1ALTA4H
SCHEMBL7152983 0.73 HIF1A (0.37) HIF1ALTA4H
SCHEMBL23760241 0.72 HIF1A (0.43) HIF1ALTA4HHRH4CYP2C9IDO1
SCHEMBL4863671 0.72 HIF1A (0.36) HIF1ALTA4H
SCHEMBL24236957 0.72 ADA (0.58) ADA
SCHEMBL5674564 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6590083-B1 Compounds of given formula; erythromycin derivatives; useful in the treatment of bacterial and protozoal infections and conditions involving gastric motility ORTHO-MCNEIL PHARMACEUTICAL, INC. 2003-07-08 US disclosed
US-6458771-B1 SERIES OF KETOLIDE ANTIBACTERIALS IN THE MACROLIDE FAMILY, DRUGS AND INTERMEDIATES, ERYTHROMYCIN ANALOGUES USEFUL IN THE TREATMENT OF BACTERIAL AND PROTOZOAL INFECTIONS AND IN THE TREATMENT OF GASTRIC MOTILITY ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-10-01 US disclosed
US-6399582-B1 GASTROINTESTINAL DISORDERS ORTHO-MCNEIL PHARMACEUTICAL, INC. 2002-06-04 US disclosed
EP-1171447-A2 KETOLIDE ANTIBACTERIALS Ortho-McNeil Pharmaceutical, Inc. (US) 2002-01-16 EP disclosed
WO-2000062783-A2 KETOLIDE ANTIBACTERIALS ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) 2000-10-26 WO disclosed