Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865265 | 0.74 | MEN1 (0.37) | KMT2A | |
| SCHEMBL1106477 | 0.74 | HIF1A (0.45) | HIF1ALTA4HKMT2A | |
| SCHEMBL20664871 | 0.72 | HIF1A (0.44) | HIF1ALTA4HMKNK1MKNK2KMT2A | |
| SCHEMBL7196866 | 0.72 | HIF1A (0.37) | HIF1ALTA4H | |
| SCHEMBL23760241 | 0.71 | HIF1A (0.43) | HIF1ALTA4HMKNK1MKNK2KMT2A | |
| SCHEMBL4868652 | 0.71 | LTA4H (0.52) | LTA4HMKNK1MKNK2KMT2A | |
| SCHEMBL21591572 | 0.71 | HIF1A (0.39) | HIF1ALTA4HMKNK1MKNK2KMT2A | |
| SCHEMBL22606405 | 0.70 | HIF1A (0.43) | HIF1A | |
| SCHEMBL21311454 | 0.70 | HIF1A (0.36) | HIF1ALTA4H | |
| SCHEMBL4867446 | 0.69 | LTA4H (0.50) | LTA4HKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332476-B2 | Pyridyl substituted ketolide antibiotics | NOVARTIS AG (CH) | 2008-02-19 | — | — | US | disclosed |
| US-20050009764-A1 | Pyridyl substituted ketolide antibiotics | CHIRON CORPORATION (US) | 2005-01-13 | — | — | US | disclosed |
| US-6756359-B2 | ADMINISTERING A 14 MEMBERED MACROLIDE AND KETOLIDE ANTIBIOTICS CONTAINING C12 MODIFICATIONS TO A PATIENT SUFFERING FROM BACTERIAL INFECTIONS | CHIRON CORPORATION | 2004-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009764-A1 | Pyridyl substituted ketolide antibiotics | PKLR, KHK, PGD | HIF1A 4418/4885LTA4H 456/4885MKNK1 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.