Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710578 | 0.85 | BRS3 (0.52) | BRS3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL713791 | 0.82 | BRS3 (0.44) | BRS3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL714120 | 0.81 | BRS3 (0.45) | BRS3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL712978 | 0.79 | BRS3 (0.49) | BRS3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL712210 | 0.72 | RAB9A (0.64) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13358775 | 0.70 | KMT2A (0.42) | BRS3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL10578851 | 0.69 | BRS3 (0.74) | BRS3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Azeloprazole SCHEMBL710150 | 0.68 | KMT2A (0.40) | BRS3CYP1A2CYP3A4CYP2C9CYP2C19 | |
| Azeloprazole SCHEMBL4333430 | 0.68 | KMT2A (0.40) | BRS3CYP1A2CYP3A4CYP2C9CYP2C19 | |
| Azeloprazole SCHEMBL31312701 | 0.68 | KMT2A (0.40) | BRS3CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124780-B2 | Benzimidazole compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |