Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.87 |
| ▸ | CMA1 | P23946 | 1/20 | 0.58 |
| ▸ | CTRC | Q99895 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050184 | 0.93 | ELANE (1.00) | ELANE | |
| SCHEMBL29706324 | 0.93 | ELANE (1.00) | ELANE | |
| SCHEMBL7003169 | 0.93 | ELANE (1.00) | ELANE | |
| SCHEMBL7003495 | 0.93 | ELANE (1.00) | ELANE | |
| SCHEMBL7204887 | 0.93 | ELANE (0.80) | ELANECMA1 | |
| SCHEMBL7004601 | 0.89 | ELANE (1.00) | ELANE | |
| SCHEMBL7202064 | 0.88 | ELANE (0.76) | ELANE | |
| SCHEMBL7199752 | 0.84 | ELANE (0.68) | ELANE | |
| SCHEMBL7203045 | 0.83 | ELANE (0.82) | ELANE | |
| Freselestat SCHEMBL7004023 | 0.82 | ELANE (1.00) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6656911-B2 | Oxadiazole ring structure peptoids which are useful as inhibitors of serine proteases | CORTECH, INC. | 2003-12-02 | — | — | US | claimed |
| US-20030203851-A1 | Substituted oxadiazole, peptoids which are useful for treating adult respiratory distress syndrome, septic shock and myocardial ischemia-reperfusion injury | CORTECH, INC. | 2003-10-30 | — | — | US | claimed |
| EP-0954526-A2 | SERINE PROTEASE INHIBITORS | CORTECH, INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1998024806-A2 | SUBSTITUTED OXADIAZOLE, THIADIAZOLE AND TRIAZOLE SERINE PROTEASE INHIBITORS | CORTECH, INC. (US) | 1998-06-11 | — | — | WO | claimed |
| US-6656911-B2 | Oxadiazole ring structure peptoids which are useful as inhibitors of serine proteases | CORTECH, INC. | 2003-12-02 | — | — | US | disclosed |
| US-20030203851-A1 | Substituted oxadiazole, peptoids which are useful for treating adult respiratory distress syndrome, septic shock and myocardial ischemia-reperfusion injury | CORTECH, INC. | 2003-10-30 | — | — | US | disclosed |
| US-6608175-B2 | Oxadiazole, thiadiazoles or triazole metal derivatives reacted with an amine containing aldehyde, deprotecting, coupling with an acid and oxidizing to create substituted oxadiazole, thiadiazole or triazole peptoids | CORTECH, INC. | 2003-08-19 | — | — | US | disclosed |
| US-20020119998-A1 | Serine protease inhibitors | CORTECH, INC. | 2002-08-29 | — | — | US | disclosed |
| US-20020119985-A1 | Serine protease inhibitors | CORTECH, INC. | 2002-08-29 | — | — | US | disclosed |
| US-6150334-A | SUBSTITUTED OXADIAZOLE, THIADIAZOLE AND TRIAZOLE STRUCTURES WHICH ARE USEFUL AS INHIBITORS OF SERINE PROTEASES, INCLUDING HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. | 2000-11-21 | — | — | US | disclosed |
| US-6015791-A | Serine protease inhibitors-cycloheptane derivatives | CORTECH INC. (US) | 2000-01-18 | — | — | US | disclosed |
| US-6001811-A | TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPSIS, MULTIPLE ORGAN FAILURE | CORTECH INC. (US) | 1999-12-14 | — | — | US | disclosed |
| US-5998379-A | USEFUL AS INHIBITORS OF SERINE PROTEASES, IN PARTICULAR HUMAN NEUTROPHIL ELASTASE, TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPTIC SHOCK, AND MYOCARDIAL ISCHEMIA-REPERFUSION INJURY | CORTECH INC. (US) | 1999-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119985-A1 | Serine protease inhibitors | PRSS1, SERPINB1, SERPINE1 | ELANE 61/4885CMA1 370/4885CTRC 393/4885 |
| US-20030203851-A1 | Substituted oxadiazole, peptoids which are useful for treating adult respiratory distress syndrome, septic shock and myocardial ischemia-reperfusion injury | TNNI3, PEPD, STK35 | ELANE 127/4885CMA1 1159/4885CTRC 1157/4885 |
| US-20020119998-A1 | Serine protease inhibitors | PRSS1, SERPINB1, SERPINE1 | ELANE 61/4885CMA1 370/4885CTRC 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.