Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.50 |
| ▸ | AR | P10275 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019818 | 1.00 | PGR (0.50) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8768221 | 1.00 | PGR (0.50) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8536675 | 1.00 | PGR (0.50) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8653821 | 0.95 | PGR (0.47) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8541351 | 0.88 | PGR (0.53) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8541353 | 0.88 | PGR (0.53) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8538261 | 0.88 | PGR (0.53) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8539945 | 0.88 | PGR (0.48) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL9019835 | 0.87 | PGR (0.49) | PGRNR3C1ARCYP3A4ABCB11 | |
| SCHEMBL8540843 | 0.86 | PGR (0.53) | PGRNR3C1ARCYP3A4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6596713-B1 | Antigestagenic, antiglucocorticoidal, antimineralcorticoidal or antiandrogenic effect | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-07-22 | — | — | US | disclosed |
| EP-0404283-B1 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AG (DE) | 1996-05-08 | — | — | EP | disclosed |
| EP-0404283-A2 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-12-27 | — | — | EP | disclosed |