Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.58 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.58 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.48 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 2/20 | 0.41 |
| ▸ | GRM8 | O00222 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Homocysteine SCHEMBL28053941 | 1.00 | PTGS1 (0.58) | PTGS1GSTK1SLC7A11GLO1ALDH1A1 | |
| Cysteine SCHEMBL6014796 | 0.90 | PTGS1 (0.61) | PTGS1GSTK1SLC7A11GLO1ALDH1A1 | |
| Cysteine SCHEMBL6014792 | 0.90 | PTGS1 (0.61) | PTGS1GSTK1SLC7A11GLO1ALDH1A1 | |
| SCHEMBL30658867 | 0.88 | PTGS1 (0.50) | PTGS1GSTK1SLC7A11GLO1ALDH1A1 | |
| SCHEMBL213626 | 0.88 | PTGS1 (0.53) | PTGS1GSTK1SLC7A11ALDH1A1MAPT | |
| SCHEMBL213625 | 0.88 | PTGS1 (0.53) | PTGS1GSTK1SLC7A11ALDH1A1MAPT | |
| SCHEMBL11766266 | 0.88 | PTGS1 (0.53) | PTGS1GSTK1SLC7A11ALDH1A1MAPT | |
| SCHEMBL27574429 | 0.88 | PTGS1 (0.53) | PTGS1GSTK1SLC7A11ALDH1A1MAPT | |
| SCHEMBL16057206 | 0.87 | PTGS1 (0.56) | PTGS1GSTK1SLC7A11GLO1ALDH1A1 | |
| Glutamine SCHEMBL10339777 | 0.86 | PTGS1 (0.62) | PTGS1GSTK1SLC7A11GLO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589751-B2 | Antibody specific for homocystamide adducts, such as those formed by dehydrating homocysteine to homocysteine thiolactone and reaction this with a carrier such as low density lipoprotein (LDL) to form homocystamide-LDL adduct | MCW RESEARCH FOUNDATION | 2003-07-08 | — | — | US | disclosed |
| US-20020015968-A1 | IMMUNOLOGICAL DETECTION OF THE HOMOCYSTAMIDE ADDUCT AND A THIOLACTONE IMMUNOASSAY FOR ENDOGENEOUS HOMOCYSTEINE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-02-07 | — | — | US | disclosed |